Spectrophotometric determination of chlorpheniramine with Plasmocorinth B

Abstract

A number of spectrophotometric methods have been given for the determination of chlorpheniramine, an antihistaminate, but there have been no specific reagents.
Plasmocorinth B as a metal reagent reacts with chlorpheniramine in an acidic medium to form a stable complex extractable into chloroform. The extract shows an absorption maximum at 567 mμ, and a linear relation holds between the absorbance and the chlorpheniramine concentration over 0.50.3 mg/ml. The reagent has been therefore applied to the determination. There are only few interfering substances, and the procedure is comparatively simple and seems practically useful.