1978 Volume 27 Issue 11 Pages 707-711
A spectrophotometric method for the determination of chlorpheniramine maleate (MCP) by solvent extraction with zincon has been established. MCP is extracted as a 1 : 1 ion association complex with zincon in the organic phase, and determined by measuring absorbance of the extract at 530 nm. The absorbance of the extract showed to be linear over the concentration range of (1.0×10-51.0×10-4) M MCP in aqueous solution. Assay method is as follows: One ml of a sample solution containing (1.05.0)×10-4 M MCP is taken in a test tube and 5 ml of acetate (0.1 M) buffer (pH 4.6), 1 ml of zincon solution (1.0×10-3 M) and 3 ml of water are added. This solution is shaken with 5 ml of dichloromethane for 3 min. The extract is filtered through a dry filter paper to remove water. The absorbance is measured at 530 nm against either a reagent blank or water. The method proposed has high sensitivity and is applicable to the determination of MCP in drug preparations.
