Abstract
Effect on the in vitro incorporation of P32 into nucleic acids of Ehrlich carcinoma cells was tested with two actively anti-cancerous and two inactive quinoline derivatives.
It was found that 4-nitroquinoline 1-oxide and 6-carboxy-4-nitroquinoline 1-oxide, both active, and 4-nitroquinoline, which is inactive, were markedly inhibitory to the incorporation, while quinoline 1-oxide (inactive) showed no such inhibition. A tentative conclusion was reached that the inhibition of P32 incorporation into nucleic acid by this class of compounds may depend upon the presence of nitro radical at the position 4, and may not be related to their anti-cancer action.
