THE RELATION BETWEEN CARCINOGENICITY AND CHEMICAL STRUCTURE OF CERTAIN QUINQLINE DERIVATIVES
1958 Volume 49 Issue 1 Pages 33-42
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1958 Volume 49 Issue 1 Pages 33-42
In continuation of our previous experiment which demonstrated the powerful carcinogenic activity of 4-nitroquinoline N-oxide, we tested the carcinogenicity of eight closely related derivatives, based on the classical Tsutsui method. It was found that 2-ethyl, 2-methyl, and 6-chloro derivatives of 4-nitroquinoline N-oxide were about as potent as the original compound, but that quinoline Noxide, 4-nitroquinoline and 6-nitroquinoline were non-carcinogenic.
An important conclusion was therefore arrived at that NO2 radical at the position 4 and O atom at the position 1 are both essential to the carcionogenicity of this class of molecules.
The respective role of these two components of the molecule in determining the cacinogenicity was reserved for consideration in our future investigation. The known biochemical and biological actions of 4-nitroquinoline N-oxide were discussed in connection with the carcinogenicity of this substance.
