Abstract
The substitution reaction between the nitro-group of various quinoline derivatives with SH-group was investigated under physiological conditions in vitro, and a definite relation was shown to exist between the carcinogenic action and reactivity of the nitro-group of these nitroquinoline N-oxides.
It was also shown that no reaction took place between 4-nitroquinoline N-oxide and amino acids, nucleotides as well as nucleic acid under the same experimental conditions, under which the nitro-group of this quinoline N-oxide so readily reacted with SH-group.
