TRYPTOPHAN METABOLISM IN TUMOR-BEARING ANIMALS

Abstract

The present communication deals with studies of the urinary excretions of tryptophan, kynurenine and anthranilic acid in tumor bearing rats or mice before and after the administration of tryptophan.
In the rats with cirrhotic or cancerous livers urinary excretion of tryptophan and its metabolites were less than normal. And the urinary excretion of tryptophan in tumor-bearing mice was of subnormal proportion. However, the kynurenine level in the urine was high in these mice.