Abstract
1) Rats were fed on DAB diet for 90-150 days, and catalase, nonhemin iron, copper, ascorbic acid, and riboflavin were determinted in the rat liver.
2) Hemosiderin iron in the non-cancerous part of liver maintained the level above normal during carcinogenesis, but that in the induced hepatoma was in the normal range.
3) Nucleoprotein-bound iron increased gradually after 3 months' feeding and reached maximum in the hepatoma and non-tumorous part of liver bearing hepatoma.
4) Ferritin iron of liver during carcinogenesis increased at first and then decreased, but again increased after the appearence of small cancer nodules. When large hepatoma appeared, ferritin iron in the non-tumorous part of liver was lowered under the normal. The ferritin iron content of hepatoma had the lowest value.
5) Catalase activity in the cirrhotic part of liver dropped at first, and then approached normal, but it became above normal after the appearance of small cancer nodules. Both hepatoma and non-tumorous part of liver bearing large hepatoma had definitely lower catalase activities than the normal.
6) The copper content of liver decreases gradually during DAB carcinogenesis.
7) Ascorbic acid in hepatoma and in the non-cancerous part of liver is maintained the level above normal during carcinogenesis.
8) Riboflavin in the hepatoma induced by DAB was less than that in the normal liver. During carcinogenesis, however, the lowest riboflavin content was observed in the liver of rat fed DAB for 30 days, and then the content of this vitamin approached normal.
