Abstract
By testing effect in vitro of various homologous tissue extracts under accurately defined experimental conditions it was demonstrated that normal liver contains a potent carcinostatic factor, which other tissues failed to yield. The complete failure of the tumor cells to take, when implanted into susceptible host, was brought about by allowing only 2cc of centrifuged supernatant of mouse liver homogenate, prepared at the rate of 1g of liver in 10cc of normal salt solution, to interact with 2cc ascites equivalent of Ehrlich carcinoma cells at 37°C for 1 hour.
The distinction of this liver factor from the well known oncolytic system of certain heterologous blood sera was pointed out and the possibility of the hepatogenic carcinostatic factor playing a deciding role in the disposal of isolated cancer cells in body fluid and consequently in preventing the formation of metastasis was considered. The importance of homologous carcinostatic system, contrasted to the heterologous one hitherto studied, was especially emphasized.
