EFFECT OF SARCOMYCIN DERIVATIVES ON SOLID TUMORS

Antonio CAPUTO; Maurizio BRUNORI; Raffaele GIULIANO

doi:10.20772/cancersci1959.53.4_371

Istituto di Chimica, Farmaceutica, e Tossicologica, University of Bari">Antonio CAPUTO, Istituto di Chimica, Farmaceutica, e Tossicologica, University of Bari">Maurizio BRUNORI, Istituto di Chimica, Farmaceutica, e Tossicologica, University of Bari">Raffaele GIULIANO

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JOURNAL FREE ACCESS

1962 Volume 53 Issue 4 Pages 371-376_1

DOI https://doi.org/10.20772/cancersci1959.53.4_371

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Abstract

The antitumor action of SB₂₁ and SB₂₂, the most active compounds among 100 new Sarcomycin derivatives, has been evaluated by their inhibitory action on various types of solid tumors (Ehrlich carcinoma of the mouse; IRE reticulo-sarcoma, Walker carcino-sarcoma and SIRE fibrosarcoma of the rat).
The differential sensitivity of the various types of solid tumors and the importance of the administrative route have been deeply investigated. The effectiveness of the two compounds has been evaluated by the inhibition of the tumor growth, and by morphological and metabolic modifications following the treatment.

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