PULMONARY CARCINOMA INDUCED BY A SINGLE SUBCUTANEOUS INJECTION OF 4-NITROQUINOLINE 1-OXIDE INTO NEW-BORN MICE

Abstract

New-born Swiss mice were injected subcutaneously with 50-200μg 4-nitroquinoline 1-oxide. In 98% of mice sacrificed after 6 months, adenomas were found in the lung, and 34.8% had well-developed adenocarcinomas.