PRIMING ACTIVITY FOR RNA SYNTHESIS OF CHROMATIN FROM TRANSPLANTABLE HEPATOMAS AND LIVERS OF TUMOR-BEARING RATS
1967 Volume 58 Issue 1 Pages 55-59
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1967 Volume 58 Issue 1 Pages 55-59
The priming activity for support of DNA-dependent RNA synthesis of chromatin isolated from transplantable rat hepatomas, Morris-5123 and HDEN-10893, from livers of rats bearing these hepatomas and from respective normal control livers was determined. The chromatin from the liver of rats bearing either Morris-5123 or HDEN-10893 showed significantly higher priming activity than that of control liver and that of the tumor tissues, while the chromatin of tumor tissues, irrespective of their growth rate, exhibited almost the same priming activity of that of the normal liver. The effect of Actinomycin-D and ammonium sulfate on the priming activity of these chromatins was also examined.
