IMMUNOCHEMICAL STUDIES ON THE LIVER CATALASE DEPRESSION BY TOXOHORMONE

Abstract

By means of quantitative immunochemical assay as well as activity determinations, depression of catalase in livers of mice injected with toxohormone was studied. The rate of reduction in the activity of liver catalase was found to be proportional to that in the actual concentration of the enzyme protein.
Depression of the activity of liver catalase by toxohormone was considered to be due to the decreased rate of synthesis of the enzyme protein, taking the result of our previous experiment into account.
Heterogeneity of chromatographic pattern of liver catalase of mouse in the course of purification of this enzyme is discussed, suggesting possible presence of isozymes of catalase in the mouse liver.