ORGAN DISTRIBUTION OF 3-METHYLCHOLANTHRENE AFTER REPEATED PAINTING AND ORAL ADMINISTRATION IN RELATION TO THE INDUCTION OF LEUKEMIA IN MICE
1968 Volume 59 Issue 3 Pages 223-229
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1968 Volume 59 Issue 3 Pages 223-229
When 3-methylcholanthrene is administered to the RF mouse, the quantity of 3-methylcholanthrene excreted in the urine is only about 3% of the total administered and the majority of such methylcholanthrene is excreted within 24 hours. 3-Methyl-cholanthrene concentration in various organs was measured with lapse of time after repeated oral administration and painting. In the orally administered group, a high methylcholanthrene concentration in bone marrow is extremely specific, and its accumulation is clearly recognized also in lymph nodes and thymus. In the painted group, a high accumulation of 3-methylcholanthrene was observed in bone marrow and thymus, followed by lymph nodes and spleen.
The presence of a close correlation between organ distribution of 3-methyl-cholanthrene and induction of leukemia is pointed out and the significance of these findings in chemical leukemogenesis is discussed.
