CYTOLOGICAL STUDIES OF TUMORS
XLIX. CHRONIC LYMPHOCYTIC LEUKEMIA WITH A1/G CHROMO-SOME TRANSLOCATION AND HIGH SERUM γ-GLOBULIN PRODUCTION
1970 Volume 61 Issue 1 Pages 1-6
Details
1970 Volume 61 Issue 1 Pages 1-6
A case of chronic lymphocytic leukemia was reported which was characterized by cells with a presumptive A1/G translocation, and an extremely high serum γ-globulin content. It was shown in the blood culture that, under the influence of phytohemagglutinin, mitosis of non-leukemic lymphocytes became predominant over that of leukemic lymphocytes with the A1/G translocation, while A1/G cells comprised one-half of the metaphase population grown without phytohemagglutinin. At least three kinds of lymphocytes were present; leukemic lymphocytes with or without the A1/G translocation dividing in vitro without phytohemagglutinin, and normal lymphocytes proliferating only under phytohemagglutinin stimulation.
The amount of serum γ-globulin was extremely high in this patient. Analyses by immunoelectrophoresis and immunoplate revealed a striking increase of IgG. It is not clear in the present case whether or not the A1/G cells are related to the elevated production of γ-globulin.
