EFFECT OF ALKYLATING AGENTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY OF ASCITES TUMOR CELLS

Abstract

Glycogen phosphorylase activity of Yoshida sarcoma was decreased by nitrogen mustard N-oxide (Nitromin) in vivo, though the decreasing rate was not remarkable. This agreed with the increase of glycogen content in Yoshida sarcoma treated with several alkylating agents.
The liver of Yoshida sarcoma-bearing rat showed lower activity of glycogen phosphorylase than that of normal rat liver, but the activity recovered to the original level by treatment with Nitromin, while no effect was observed in normal rat liver by this treatment.