ANTIGENIC MODIFICATION OF RAT TUMOR CELLS ARTIFICIALLY INFECTED WITH FRIEND VIRUS IN THE PRIMARY AUTOCHTHONOUS HOST

Abstract

The present experiments demonstrated that Friend virus-infected tumor cells transplanted into primary autochthonous hosts did not grow well and later regressed spontaneously, while transplanted non-infected primary tumor cells grew well and killed the host. Primary tumor cells infected with Friend virus, however, grew well in the Friend virus-tolerant rats and killed them. From these experiments it was concluded that the antigenic modification of tumor antigens by an artificial infection of the virus may be observed not only in the isologous systems as previously reported, but also in the autochthonous host as indicated in the present experiment.