Abstract
The growth of primary fibrosarcomas induced by 3-methylcholanthrene in rats was inhibited by the intravenous injection of spleen and lymph-node cells obtained from allogeneic rats specifically immunized with a heavily irradiated piece of the tumor to be treated. In 12 out of 18 animals (66%), marked slowing of tumor growth or regression occurred without any sign of graft vs. host reaction and effect of the treatment seems to depend on the action of lymphoid cells which were immunized against tumor-specific antigens.
In a series of 14 animals treated with non-immune lymphoid cells, marked slowing of tumor growth and regression occurred in 5 (35%). The non-immune lymphoid cells also caused graft vs. host reaction in some rats, but this did not always occur in association with the antitumor effect.
