CARCINOGENIC ACTIVITY OF 5-HYDROXY-3, 4-BENZOPYRENE

Abstract

5-Hydroxy-3, 4-benzopyrene which has been reported to be non-carcinogenic was found to be weakly carcinogenic. This result is discussed in relation to our previous finding that 5-Hydroxy-3, 4-benzopyrene was easily converted to 5-phenoxy radical and this free radical was produced from 3, 4-benzopyrene enzymically when incubated with skin or liver sap.