PERITONEAL BLEEDING OF THE RAT BEARING ASCITES HEPATOMA, AH-13

Abstract

The growth of an ascites hepatoma, AH-13, in the rat was always accompanied by a strong peritoneal bleeding. Rats given a lyophilized powder of tumor cells intraperitoneally bled and a similar bleeding was also observed on administration of the lyophilized powder of a normal rat liver. The ribosomes or the smooth endoplasmic reticulum of the rat liver had the bleeding activity. Intraperitoneal injection of the smooth endoplasmic reticulum of the liver resulted in the appearance of a large number of macrophages followed by a strong peritoneal bleeding. During the growth of tumor cells in vivo the number of degenerated cells in the ascites should be increased and the ribosomes released from damaged cells play a part in the peritoneal bleeding of the host animals.