INCREASED PRODUCTION OF α-FETOPROTEIN BY CYCLIC 3', 5'-ADENOSINE MONOPHOSPHATE-TREATED YOSHIDA ASCITES SARCOMA CELLS IN VITRO

Hidehiko ISAKA; Sumiko UMEHARA; Makoto UMEDA; Hidematsu HIRAI; Yutaka TSUKADA; Hiroyuki WATABE

doi:10.20772/cancersci1959.65.1_79

INCREASED PRODUCTION OF α-FETOPROTEIN BY CYCLIC 3', 5'-ADENOSINE MONOPHOSPHATE-TREATED YOSHIDA ASCITES SARCOMA CELLS IN VITRO

Hidehiko ISAKA, Sumiko UMEHARA, Makoto UMEDA, Hidematsu HIRAI, Yutaka TSUKADA, Hiroyuki WATABE

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Keywords: α-Fetoprotein, Cyclic AMP, Yoshida sarcoma cells, cultured

JOURNAL FREE ACCESS

1974 Volume 65 Issue 1 Pages 79-83

DOI https://doi.org/10.20772/cancersci1959.65.1_79

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Abstract

An α-fetoprotein-producing clone of Yoshida sarcoma was cultivated in vitro in a medium containing various concentrations of cyclic AMP. The growth of Yoshida cells was lowered, accompanying depressed DNA and RNA syntheses but increased protein synthesis, and the production of α-fetoprotein in the growth-depressed cells was accelerated.

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