1974 Volume 65 Issue 6 Pages 493-505
The oil-attached cell-wall skeletons of mycobacteria, nocardia, and corynebacteria, and peptidoglycolipid of Mycobacterium tuberculosis Aoyama B weree valuated for antitumor activity in the prevention of tumor growth of melanoma-B16, mastocytoma P815-X2, and EL-4 leukemia in syngeneic mice. When tumor growth was suppressed, specific and systemic tumor immunity to a subsequent tumor challenge was always demonstrated in mice. It was found that specific tumor immunity was induced by the intradermal injection of a mixture of oil-attached BCG cell-wall skeleton and irradiated or Mitomycin-C treated mastocytoma-P815 cells in syngeneic mice. The intravenous injection of oil-attached BCG cell-wall skeleton prevents the induction of lung cancer in rabbits by the instillation of a mixture of 3-methylcholanthrene and 4-nitroquinoline 1-oxide in rabbit plasma.
