DEVELOPMENT OF ADENOCARCINOMA OF THE PROSTATE IN ICR MICE LOCALLY IRRADIATED WITH X-RAYS

Abstract

The pelvic region of male ICR/JCL mice 5∼7 weeks of age was irradiated with 1, 000 rad of X-ray for a total of 8 exposures to determine whether such irradiation would induce prostatic carcinoma. Prostatic adenocarcinoma was observed in 5 of 135 animals which survived more than 12 weeks after the first X-iriaradtion. Because spontaneous development of prostatic adenocarcinoma has not been reported in mice, development of this carcinoma in these animals can be considered to be attributable to X-irradiation.