COMPARATIVE STUDIES OF THE ANTITUMOR EFFECT ON INTRAVENOUS ADMINISTRATION OF CARBAZILQUINONE AND MITOMYCIN-C

Abstract

Comparison between Carbazilquinone and Mitomycin-C, both of which contain aziridinyl, carbamoyloxy, and quinonyl groups, was made for their therapeutic effect upon intravenous administration. Although both agents exhibited a significant effect on plasmacytoma X5563 in C3H/He mice to a similar extent, Mitomycin-C was not as effective on lympholeukemia L-1210 and on the lung metastasis of Ehrlich carcinoma in (C57BL/6 × DBA/2)F₁ (BDF₁) mice as was Carbazilquinone. Possible interpretations regarding this discrepancy are discussed.