EFFECT OF DIETHYLSTILBESTROL ON THE CELL KINETICS OF SUBCUTANEOUS GROWTH OF DIETHYLSTILBESTROL-INDUCED RENAL CARCINOMA

Abstract

A response to diethylstilbestrol (DES) of DES-induced renal carcinoma in Syrian hamster was studied by comparing subcutaneous growth of this tumor in DES-treated and untreated animals with respect to the growth curve, cell cycle time, T_c, growth fraction, GF, and cell loss factor, φ. In both conditions the tumor growth followed the Gompertz curve, but the latent period was 14 days longer without DES than with DES. In the untreated animals T_c was 80% longer due to increases of T_Gl and T_S. However, φ was not changed significantly and GF rather increased without DES. It was concluded that DES-dependency of this tumor growth was manifested in the prolongation of T_c.