STIMULATION OF A RECONSTITUTED, MICROSOMAL NADH OXIDASE SYSTEM BY CARBOQUONE, A QUINOID ANTICANCER CHEMICAL

Abstract

Carboquone was found to greatly stimulate the aerobic NADH oxidation in the presence of both the partially purified NADH-cytochrome b₅ reductase and cytochrome b₅ prepared from hepatic microsomes by acting as an electron carrier from cytochrome b₅ to molecular oxygen. Other quinoid anticancer chemicals, mitomycin-C, adriamycin, and daunomycin practically failed to do so.