INDUCTION OF RAT LUNG CARCINOMA BY A SINGLE INJECTION OF N-BIS (2-HYDROXYPROPYL) NITROSAMINE

Yoichi KONISHI; Tomikazu IKEDA; Akiko KAWABATA; Hitoshi YOSHIMURA; Riichiro MIKAMI

doi:10.20772/cancersci1959.69.6_855

Yoichi KONISHI, Tomikazu IKEDA, Akiko KAWABATA, Hitoshi YOSHIMURA, Riichiro MIKAMI

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Keywords: Chemical carcinogenesis, N-Bis(2-hydroxypropyl)nitrosamine, Lung cancer, Nitrosamine, Wistar rat

JOURNAL FREE ACCESS

1978 Volume 69 Issue 6 Pages 855-856

DOI https://doi.org/10.20772/cancersci1959.69.6_855

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Abstract

Lung carcinoma was induced by a single intraperitoneal injection of 3g/kg and 4g/kg body weight of DHPN in male Wistar rats. The incidence of adenomas was 100%, and that of adenocarcinomas was 82% and 75%, respectively, after 52 weeks.

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