ANTITUMOR ACTIVITY OF 7-N-PHENYL DERIVATIVES OF MITOMYCIN C IN THE LEUKEMIA P388 SYSTEM

Abstract

The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration. The compounds tested were 7-N-phenyl-, 7-N-(p-aminophenyl)-, 7-N-(p-hydroxyphenyl)- and 7-N-(p-chlorophenyl)-mitolnycin C. The maximum increases in life span (ILS_max) obtained were 124, 169, >386 and 112%, respectively, that with mitomycin C being 104%. 7-N-(p-Hydroxyphenyl)-mitomycin C showed a higher ILS% than its ortho and meta isomers. Thus, 7-N-(p-hydroxyphenyl)-mitomycin C was the most effective of these compounds.