γ-IRRADIATION INDUCES MUTATION IN ATAXIA-TELANGIECTASIA LYMPHOBLASTOID CELLS

Abstract

Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of γ-rays, whereas little or no γ-ray induced mutation has been observed. In this work, exposure to γ-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.