DEMONSTRATION OF CARCINOGENICITY IN F344 RATS OF 2-AMINO-3-METHYL-IMIDAZO[4, 5-f]QUINOLINE FROM BROILED SARDINE, FRIED BEEF AND BEEF EXTRACT

Shozo TAKAYAMA; Yoko NAKATSURU; Mitsunobu MASUDA; Hiroko OHGAKI; Shigeaki SATO; Takashi SUGIMURA

doi:10.20772/cancersci1959.75.6_467

Shozo TAKAYAMA, Yoko NAKATSURU, Mitsunobu MASUDA, Hiroko OHGAKI, Shigeaki SATO, Takashi SUGIMURA

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Keywords: 2-Amino-3-methylimidazo[4,5-f]-quinoline, Carcinogenicity, Rats

JOURNAL FREE ACCESS

1984 Volume 75 Issue 6 Pages 467-470

DOI https://doi.org/10.20772/cancersci1959.75.6_467

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Abstract

The mutagenic compound 2-amino-3-methylimidazo[4, 5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.

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