METHYLATION PATTERN OF THE BOVINE LEUKEMIA PROVIRUS GENOME IN BOVINE LEUKEMIC CELLS

Yasuki OGAWA; Noriyuki SAGATA; Junko TSUZUKU-KAWAMURA; Misao ONUMA; Hisao IZAWA; Yoji IKAWA

doi:10.20772/cancersci1985.76.1_5

Yasuki OGAWA, Noriyuki SAGATA, Junko TSUZUKU-KAWAMURA, Misao ONUMA, Hisao IZAWA, Yoji IKAWA

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Keywords: Bovine leukosis, Bovine leukemia virus expression, Proviral methylation, pX_BL region

JOURNAL FREE ACCESS

1985 Volume 76 Issue 1 Pages 5-8

DOI https://doi.org/10.20772/cancersci1985.76.1_5

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Abstract

All the known genes of the bovine leukemia proviral genome were found to be heavily methylated in both fresh and short-term-cultured leukemic cells, the latter of which expressed viral antigens. However, the pX_BL region appeared to be mostly demethylated or at least hypomethylated in both cells, indicating that there is a non-uniform methylation pattern of the proviral genome.

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