THE H-2 COMPLEX AFFECTS THE FREQUENCY OF URETHAN-INDUCED CHROMOSOMAL ABERRATIONS

Abstract

We have already found that H-2 complex has an apparent effect on the development of lung tumors in mice. In connection with this finding, the incidence of in vivo urethan-induced chromosomal aberrations of bone marrow cells was examined in H-2 congenic strains. These strains could be divided into two groups, one with a higher frequency of chromosomal aberrations such as A.AL (H-2^a1), A.TL (H-2^t1), B10.A (H-2^a) and B10.S (9R) (H-2^t4), and the other with a lower incidence such as B10 (H-2^b), A.SW (H-2^s), B10.S (H-2^s) and B10.S(7R) (H-2^t2). These results suggested that a putative gene mapped to the chromosomal segment between Eβ and D may affect the incidence of urethan-induced chromosomal aberrations.