AMPLIFICATION AND ENHANCED EXPRESSION OF CELLULAR ONCOGENE c-Ki-ras-2 IN A HUMAN EPIDERMOID CARCINOMA OF THE LUNG

Michiko MIYAKI; Chieko SATO; Takane MATSUI; Morio KOIKE; Takeo MORI; Goro KOSAKI; Setsuo TAKAI; Akira TONOMURA; Nobuo TSUCHIDA

doi:10.20772/cancersci1985.76.4_260

AMPLIFICATION AND ENHANCED EXPRESSION OF CELLULAR ONCOGENE c-Ki-ras-2 IN A HUMAN EPIDERMOID CARCINOMA OF THE LUNG

Michiko MIYAKI, Chieko SATO, Takane MATSUI, Morio KOIKE, Takeo MORI, Goro KOSAKI, Setsuo TAKAI, Akira TONOMURA, Nobuo TSUCHIDA

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Keywords: Gene amplification, c-Ki-ras-2, Enhanced expression, Chromosome abnormality, Human lung carcinoma

JOURNAL FREE ACCESS

1985 Volume 76 Issue 4 Pages 260-265

DOI https://doi.org/10.20772/cancersci1985.76.4_260

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Abstract

The level of c-Ki-ras-2-specific mRNA was found to be markedly enhanced (10- to 20-fold) in a human epidermoid lung carcinoma transplanted into nude mice, compared with that in other lung carcinomas. Analysis of DNA revealed that c-Ki-ras-2 gene was amplified approximately 10-fold in this carcinoma, while c-Ha-ras, c-myc and c-sis were not amplified. Chromosome abnormalities were also observed in this carcinoma.

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