ACTIVATED ONCOGENES IN A RAT HEPATOCELLULAR CARCINOMA INDUCED BY 2-AMINO-3-METHYL-IMIDAZO [4, 5-f]QUINOLINE

Fuyuki ISHIKAWA; Fumimaro TAKAKU; Minako NAGAO; Masako OCHIAI; Kenshi HAYASHI; Shozo TAKAYAMA; Takashi SUGIMURA

doi:10.20772/cancersci1985.76.6_425

Fuyuki ISHIKAWA, Fumimaro TAKAKU, Minako NAGAO, Masako OCHIAI, Kenshi HAYASHI, Shozo TAKAYAMA, Takashi SUGIMURA

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Keywords: 2-Amino-3-methylimidazo[4,5 f]quinoline, Hepatocellular carcinoma, Rat oncogene, H-ras-1

JOURNAL FREE ACCESS

1985 Volume 76 Issue 6 Pages 425-428

DOI https://doi.org/10.20772/cancersci1985.76.6_425

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Abstract

The presence of activated oncogenes in several rat hepatocellular carcinomas induced by 2-amino-3-methylimidazo [4, 5-f]quinoline (IQ) was examined by NIH 3T3 cell transfection assay and Southern blot analysis. In one tumor, IQ4, rat H-ras-1 and another oncogene that did not belong to the ras family were found to be activated.

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