T CELL RECEPTOR β CHAIN GENE REARRANGEMENTS IN LEUKEMIAS WITH IMMATURE T CELL PHENOTYPE

Hirotaka SUZUKI; Ryuzo UEDA; Yuichi OBATA; Masao SETO; Ryo HIRATA; Haruki IWAMURA; Kazuo OTA; Toshitada TAKAHASHI

doi:10.20772/cancersci1985.77.11_1069

Hirotaka SUZUKI, Ryuzo UEDA, Yuichi OBATA, Masao SETO, Ryo HIRATA, Haruki IWAMURA, Kazuo OTA, Toshitada TAKAHASHI

Author information

Hirotaka SUZUKI
The First Department of Internal Medicine, Nagoya University School of Medicine
Ryuzo UEDA
The Laboratories of Chemotherapy and Immunology, Aichi Cancer Center Research Institute
Yuichi OBATA
The Laboratories of Chemotherapy and Immunology, Aichi Cancer Center Research Institute
Masao SETO
The Laboratories of Chemotherapy and Immunology, Aichi Cancer Center Research Institute
Ryo HIRATA
The Department of Pediatrics, Nagoya University School of Medicine
Haruki IWAMURA
The Department of Pediatrics, Nagoya University School of Medicine
Kazuo OTA
The Laboratories of Chemotherapy and Immunology, Aichi Cancer Center Research Institute
Toshitada TAKAHASHI
The Laboratories of Chemotherapy and Immunology, Aichi Cancer Center Research Institute

Keywords: T cell receptor gene, Acute lymphocytic leukemia, Chronic myelocytic leukemia in blastic crisis, Immature T cell phenotype

JOURNAL FREE ACCESS

1986 Volume 77 Issue 11 Pages 1069-1073

DOI https://doi.org/10.20772/cancersci1985.77.11_1069

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Abstract

The arrangements of the T cell receptor (TCR) β genes were studied in leukemias with immature T cell phenotype. Three cases of acute lymphocytic leukemia (ALL) and one case of chronic myelocytic leukemia in blastic crisis (CML-BC), which expressed only Tp40 antigen of cluster of differentiation (CD) 7 without erythrocyte rosette receptor (E), did not show rearrangements of TCR β chain genes. Two of 5 ALL cases which expressed an additional T cell antigen, TI of CD5, showed rearrangements of TCR β genes. Two cases of CML-BC expressing T1 and Tp40, however, had unrearranged TCR β genes. The results altogether showed that a part of E^- T1⁺ Tp40⁺ ALL cases is of T cell origin.

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