INHIBITORY EFFECT OF DIBUTYLTIN DICHLORIDE ON PANCREATIC ADENOCARCINOMA DEVELOPMENT BY N-NITROSOBIS(2-OXOPROPYL)AMINE IN THE SYRIAN HAMSTER

Abstract

The effects of a single intragastric application of dibutyltin dichloride (DT), at a dose of 30mg/kg body weight, on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis were studied in female Syrian golden hamsters. DT, which has been shown to selectively induce bile duct injury, was administered either 1 week before or after BOP initiation. BOP was injected subcutaneously once a week for 5 weeks at a dose of 10mg/kg body weight. Controls were injected with BOP alone or given DT without carcinogen. Animals sacrificed at the end of the 25-week experimental period showed a significant inhibitory effect of DT on pancreatic carcinoma induction when DT was given before BOP treatment, although no such influence was evident with DT treatment following BOP exposure. These results indicate that the bile duct and more especially common bile-duct injury induced by DT may be relevant to the inhibition of the initiation stage of BOP-induced pancreatic carcinoma development in Syrian hamsters.