HIGH SUSCEPTIBILITY OF ANALBUMINEMIC RATS TO GASTRIC TUMOR INDUCTION BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE

Kenji SUGIYAMA; Sumi NAGASE; Akihiko MAEKAWA; Hiroshi ONODERA; Yuzo HAYASHI

doi:10.20772/cancersci1985.77.3_219

Kenji SUGIYAMA, Sumi NAGASE, Akihiko MAEKAWA, Hiroshi ONODERA, Yuzo HAYASHI

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Keywords: N-Methyl-N'-nitro-N-nitrosoguanidine, Gastric tumor, Analbuminemia, Rat

JOURNAL FREE ACCESS

1986 Volume 77 Issue 3 Pages 219-221

DOI https://doi.org/10.20772/cancersci1985.77.3_219

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Abstract

Analbuminemic rats were found to be highly susceptible to induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine (67-83μg/ml) given to the rats in drinking water for 32 weeks. The rats were sacrificed at experimental week 44. Gastric tumors were found in 12 of 17 analbuminemic rats (70%) and in 8 of 21 normal rats (38%). Intestinal tumors developed in 7 of 17 (41%) analbuminemic rats and in 9 of 21 (42%) normal rats.

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