ANTITUMOR EFFECT OF TWO-DRUG SIMULTANEOUS OR SEQUENTIAL USE OF CISPLATIN, VINDESINE OR ETOPOSIDE ON HUMAN PULMONARY ADENOCARCINOMA CELL LINES IN TUMOR CLONOGENIC ASSAY

Yung-Chie LEE; Nagahiro SAIJO; Yasutsuna SASAKI; Hidenobu TAKAHASHI; Masanori SAKURAI; Junichi ISHIHARA; Tetsuro SANO; Akio HOSHI; Kai-Mo CHEN; Anne W. HAMBURGER

doi:10.20772/cancersci1985.77.3_312

Yung-Chie LEE, Nagahiro SAIJO, Yasutsuna SASAKI, Hidenobu TAKAHASHI, Masanori SAKURAI, Junichi ISHIHARA, Tetsuro SANO, Akio HOSHI, Kai-Mo CHEN, Anne W. HAMBURGER

Author information

Yung-Chie LEE
Department of Surgery, National Taiwan University Hospital
Nagahiro SAIJO
Pharmacology Division, National Cancer Center Research Institute
Yasutsuna SASAKI
Pharmacology Division, National Cancer Center Research Institute
Hidenobu TAKAHASHI
Department of Internal Medicine, National Cancer Center Hospital
Masanori SAKURAI
Department of Internal Medicine, National Cancer Center Hospital
Junichi ISHIHARA
Pharmacology Division, National Cancer Center Research Institute
Tetsuro SANO
Department of Internal Medicine, National Cancer Center Hospital
Akio HOSHI
Pharmacology Division, National Cancer Center Research Institute
Kai-Mo CHEN
Department of Surgery, National Taiwan University Hospital
Anne W. HAMBURGER
University of Maryland Cancer Center

Keywords: Chemosensitivity, Lung cancer cell lines, Simultaneous or sequential treatment

JOURNAL FREE ACCESS

1986 Volume 77 Issue 3 Pages 312-318

DOI https://doi.org/10.20772/cancersci1985.77.3_312

Details

Abstract

The antitumor effects of two-drug simultaneous or sequential use of cisplatin, vindesine or etoposide were examined in human pulmonary adenocarcinoma cell lines by human tumor clonogenic assay. Different tumor cell lines (PC-9, PC-13 and PC-14) that originated from the same histological cell type responded quite variably to simultaneous and/or sequential therapy. The antitumor effects of various sequential combinations of cisplatin, vindesine and etoposide depended strongly on the nature of the individual tumor cell line tested.

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