RADIOIMMUNOASSAY OF c-myc PROTEIN

Yoshihiro UCHIDA; Ken YAMAGUCHI; Kaoru ABE; Takayuki TSUCHIHASHI; Fumiki ASANUMA; Koichi NAGASAKI; Satoshi KIMURA; Noboru YANAIHARA; Norman S. TRACK

doi:10.20772/cancersci1985.77.7_615

RADIOIMMUNOASSAY OF c-myc PROTEIN

Yoshihiro UCHIDA, Ken YAMAGUCHI, Kaoru ABE, Takayuki TSUCHIHASHI, Fumiki ASANUMA, Koichi NAGASAKI, Satoshi KIMURA, Noboru YANAIHARA, Norman S. TRACK

Author information

Yoshihiro UCHIDA
Endocrinology Division, National Cancer Center Research Institute
Ken YAMAGUCHI
Endocrinology Division, National Cancer Center Research Institute
Kaoru ABE
Endocrinology Division, National Cancer Center Research Institute
Takayuki TSUCHIHASHI
Endocrinology Division, National Cancer Center Research Institute
Fumiki ASANUMA
Endocrinology Division, National Cancer Center Research Institute
Koichi NAGASAKI
Endocrinology Division, National Cancer Center Research Institute
Satoshi KIMURA
Endocrinology Division, National Cancer Center Research Institute
Noboru YANAIHARA
Laboratory of Bioorganic Chemistry, Shizuoka College of Pharmacy
Norman S. TRACK
Endocrinology Division, National Cancer Center Research Institute

Keywords: c-myc protein, Radioimmunoassay, Oncogene product, Human tumor HL-60, N231, Lu-65

JOURNAL FREE ACCESS

1986 Volume 77 Issue 7 Pages 615-619

DOI https://doi.org/10.20772/cancersci1985.77.7_615

Details

Abstract

A sensitive radioimmunoassay for human c-myc protein was developed by using an amino-terminal fragment of c-myc protein, c-myc(11-24). Immunoreactive c-myc protein was found to be present in 3 human tumors (HL-60, N231, Lu-65), which are known to have c-myc gene amplification. In contrast, c-myc protein was undetectable in 1 human tumor (H69) without c-myc gene amplification as well as in human heart tissues.

Corresponding author

Register with J-STAGE for free!