ISOLATION OF HUMAN IMMUNODEFICIENCY VIRUS FROM A JAPANESE HEMOPHILIA B PATIENT WITH AIDS

Abstract

Human immunodeficiency virus (HIV) was isolated from a Japanese hemophilia B patient with AIDS. This isolate, HIV[GUN-1], was infectious to several mature T-cell lines. Proteins with apparent molecular weights of 160, 55 and 25 kilodaltons were detected. Restriction enzyme cleavage patterns of the proviral genome indicated that HIV-[GUN-1] is related to but clearly different from HTLV-III or ARV-2.