THE COLLABORATION OF H-2 IDENTICAL BONE MARROW CELLS IN IN VIVO ANTITUMOR ACTIVITY OF IMMUNE MOUSE SPLENOCYTES

Hideki OZAWA; Takao IWAGUCHI; Tateshi KATAOKA

doi:10.20772/cancersci1985.78.2_113

THE COLLABORATION OF H-2 IDENTICAL BONE MARROW CELLS IN IN VIVO ANTITUMOR ACTIVITY OF IMMUNE MOUSE SPLENOCYTES

Hideki OZAWA, Takao IWAGUCHI, Tateshi KATAOKA

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Keywords: In vivo tumor rejection, Meth A, Chimeric nude mice, H-2 restriction, Bone marrow cells

JOURNAL FREE ACCESS

1987 Volume 78 Issue 2 Pages 113-116

DOI https://doi.org/10.20772/cancersci1985.78.2_113

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Abstract

Antitumor activity of Meth A-immune BALB/c mouse spleen cells (Meth A-Im-SPL) was assayed by a Winn test in CD-1(nu/nu) or BALB/c(nu/nu) chimeric mice which were reconstituted with the bone marrow cells of various strains of mice. It was found that Meth A-Im-SPL (L3T4⁺ T cells) neutralized the tumor in collaboration with H-2 compatible bone marrow or bone marrow-derived cells.

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