INDUCTION OF γ-GLUTAMYLTRANS-PEPTIDASE-POSITIVE FOCI IN RAT LIVER BY DEOXYCHOLIC ACID

Hitoshi URA; Yoshihiko YOKOSE; Kazuhiro MIZUMOTO; Akira NAKAJIMA; Kazuhiko YAMAMOTO; Ayumi DENDA; Yoichi KONISHI

doi:10.20772/cancersci1985.78.3_216

Hitoshi URA, Yoshihiko YOKOSE, Kazuhiro MIZUMOTO, Akira NAKAJIMA, Kazuhiko YAMAMOTO, Ayumi DENDA, Yoichi KONISHI

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Keywords: Deoxycholic acid, Lithocholic acid, γ-Glutamyltranspeptidase-positive foci, Initiating activity, Rat liver

JOURNAL FREE ACCESS

1987 Volume 78 Issue 3 Pages 216-218

DOI https://doi.org/10.20772/cancersci1985.78.3_216

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Abstract

Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of γ-glutamyltranspeptidase(GGT)-positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT-positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT-positive foci by LCA was less pronounced and was not dose-dependent. These results suggest that DCA possesses initiating activity.

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