INDUCTIONS OF ORNITHINE DECARBOXYLASE AND DNA SYNTHESIS IN RAT STOMACH MUCOSA BY 1-NITROSOINDOLE-3-ACETONITRILE

Chie FURIHATA; Yuko SATO; Akira YAMAKOSHI; Megumi TAKIMOTO; Taijiro MATSUSHIMA

doi:10.20772/cancersci1985.78.5_432

Chie FURIHATA, Yuko SATO, Akira YAMAKOSHI, Megumi TAKIMOTO, Taijiro MATSUSHIMA

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Keywords: 1-Nitrosoindole-3-acetonitrile, Tumor-initiating activity, Tumor-promoting activity, Rat stomach mucosa

JOURNAL FREE ACCESS

1987 Volume 78 Issue 5 Pages 432-435

DOI https://doi.org/10.20772/cancersci1985.78.5_432

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Abstract

Administration of 1-nitrosoindole-3-acetonitrile (NIAN) at doses of 40 to 300mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 24hr and up to 10-fold increase in DNA synthesis with a maximum after 16hr in the pyloric mucosa of the stomach. These results suggest that NIAN has potential tumor-promoting activity in carcinogenesis in the glandular stomach.

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