PROMOTING EFFECT OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON NEUROGENIC MICROTUMORS INITIATED BY TRANSPLACENTAL EXPOSURE TO N-ETHYL-N-NITROSOUREA

Abstract

The promoting effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the occurrence of neurogenic microtumors in SD-JCL rats initiated transplacentally with N-ethyl-N-nitrosourea (ENU) was investigated. The treatment with TPA induced earlier occurrence of microtumors than as compared with the initiation alone. Thus, TPA has tumor-promoting activity on the formation of neurogenic microtumors in rats prenatally exposed to ENU.