A NEW ANTI-HUMAN IMMUNODEFICIENCY VIRUS SUBSTANCE, GLYCYRRHIZIN SULFATE; ENDOWMENT OF GLYCYRRHIZIN WITH REVERSE TRANSCRIPTASE-INHIBITORY ACTIVITY BY CHEMICAL MODIFICATION

Hideki NAKASHIMA; Toshio MATSUI; Osamu YOSHIDA; Yoshikazu ISOWA; Yasuji KIDO; Yoshinobu MOTOKI; Masahiko ITO; Shiro SHIGETA; Takeo MORI; Naoki YAMAMOTO

doi:10.20772/cancersci1985.78.8_767

Hideki NAKASHIMA, Toshio MATSUI, Osamu YOSHIDA, Yoshikazu ISOWA, Yasuji KIDO, Yoshinobu MOTOKI, Masahiko ITO, Shiro SHIGETA, Takeo MORI, Naoki YAMAMOTO

Author information

Hideki NAKASHIMA
Department of Virology and Parasitology, Yamaguchi University School of Medicine
Toshio MATSUI
Department of Virology and Parasitology, Yamaguchi University School of Medicine
Osamu YOSHIDA
Department of Virology and Parasitology, Yamaguchi University School of Medicine
Yoshikazu ISOWA
Central Research Laboratory, Fujirebio Inc.
Yasuji KIDO
Ube Research Laboratory, Fujirebio Inc.
Yoshinobu MOTOKI
Ube Research Laboratory, Fujirebio Inc.
Masahiko ITO
Department of Bacteriology, Fukushima Medical College
Shiro SHIGETA
Department of Bacteriology, Fukushima Medical College
Takeo MORI
Minophagen Pharmaceutical Co.
Naoki YAMAMOTO
Department of Virology and Parasitology, Yamaguchi University School of Medicine

Keywords: Anti-retroviral drug, Glycyrrhizin, Glycyrrhizin sulfate, Human immunodeficiency virus, Reverse transcriptase inhibitor

JOURNAL FREE ACCESS

1987 Volume 78 Issue 8 Pages 767-771

DOI https://doi.org/10.20772/cancersci1985.78.8_767

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Abstract

Glycyrrhizin sulfate (GLS) was synthesized and investigated for antiviral effect on the human immunodeficiency virus (HIV) in vitro in comparison with the parental anti-HIV compound glycyrrhizin (GL). In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhibited by 0.25mg/ml (0.184 mM) of GLS. Moreover, GLS completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 1mg/ml (736μM), the 50% inhibitory dose being 0.055mg/ml (40μM). GLS was found to be an efficient inhibitor of reverse transcriptase. The effect of GLS was 4 times stronger than that of GL in molar terms.

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