Abstract
The binding of bacteria to IOLs during implantation and the colonization of IOLs by bacteria after implantation appear to contribute to the pathogenesis of postoperative endophthalmitis. We investigated the bacterial adhesion to IOLs, the bacterial infiltration to lens capsule, and the preventive effect of drug delivery IOL and SCL. Results: After 48 and 72 hrs, it was observed that silicone supported the least amount of biofilm formation (p<0.05), with acrylic demonstrating the greatest amount of stainable biofilm (p<0.0005). Staphylococcus epidermidis aggregated on the surface of anterior and posterior lens capsule at 24 hrs. MRSA strain infiltrated to the anterior and posterior lens capsule. The new drug released SCLs showed along with prevention of bacterial proliferation, and preventive effects against endophthalmitis were similar between antibiotic-treated IOL implantation and intracameral antibiotic administration.
