Abstract
Various signaling pathways are activated after cerebral ischemia. p53 plays important roles in regulation of apoptotic pathways. p53 transcriptionally activates mitochondria-dependent apoptotic pathway that involves pro- and antiapoptotic protein binding, the release of cytochrome c and apoptosis-inducing factor, leading to neuronal death after cerebral ischemia. In this report, we summarize this signaling pathway, focusing on Bcl-2-associated X protein (Bax), p53-upregulated modulator of apoptosis (PUMA), and p53-induced protein with a death domain (PIDD).
