Abstract
Establishment of human induced pluripotent cells (iPS) promises the possibility of regenerative therapy against stroke. We describe the history of neural stem cell research in brain ischemia. Effective cell transplantation against stroke needs to re-organize cortico-spinal tract including regeneration of motor neurons. Adult neurogenesis in human cannot improve functional recovery after stroke now. We are using rehabilitation using hybrid assistive limbs (HAL) to encourage neurogenesis. It is important for us to establish neurophysiological and neuroradiological assessment system based of scientific evidence.
