Abstract
American Food and Drug Administration(FDA) approved recombinant tissue plasminogen activator(rt-PA) based on the result of the NINDS study in 1996. After that, rt-PA IV therapy came to be performed widely all over the world. In Japan, use of rt-PA was approved in October, 2005. Effective possibility until onset 4.5 hours for time-window is shown in many studies and time-window was extended by 4.5 hours from September, 2012 in Japan as well as other countries. We have performed the IV-rt-PA studies based on MRI after approve of use of rt-PA. In this paper, herein, we mentioned our studies as follows, 1) DWI before the t-PA treatment and patient outcome, 2) t-PA treatment and presence of right left shunt, 3) M1 susceptibility vessel sign (M1 SVS) on T2* and early recanalization after rt-PA therapy, and 4) t-PA treatment and microbleeds on T2*.
