Brain protection in acute ischemic stroke

Abstract

Preservation of the microcirculation and inhibition of hemorrhagic transformation are the promising strategy of brain protection in the acute cerebral ischemia. It is well established that the pre-ischemic endothelial nitric oxide synthase (eNOS) condition is closely related to cerebral ischemia severity. However, there were few reports about postischemic alterations in the eNOS regulatory system. We evaluated the eNOS phosphorylation and monomerization, and found functional deterioration of eNOS after cerebral ischemia. It is serious issue of the brain protection in the acute phase of ischemia. The endothelial dysfunction after cerebral ischemia may be one of main therapeutic target in acute cerebral ischemia.