Stroke therapy through the regulation of glial cell interaction

Abstract

The brain consists of neurons as well as glial cells that outnumber neurons. There are at least three different types of glial cells; astroglia, oligodendroglia, and microglia. Our research has focused on the roles and function of astroglia with regard to metabolic compartment for decades. Recently, it has been elucidated that glial cells function coordinately, making metabolic compartment with each other. This short review introduces the importance of communication of glial cell network in the pathophysiology of stroke, leading the development of novel therapeutic strategy of ischemic stroke.